Scrabble?! ENTRES

Definitions of ENTRES in various dictionaries:

Sacubitril/valsartan, sold under the brand name Entresto among others, is a combination drug for use in heart failure developed by Novartis. It consists of the neprilysin inhibitor sacubitril and the angiotensin receptor blocker valsartan, in a 1:1 mixture by molecule count. It is recommended for use as a replacement for an ACE inhibitor or an angiotensin receptor blocker in people with heart failure with reduced ejection fraction.Potential side effects include angioedema, kidney problems, and low blood pressure. The risk of kidney problems and increased levels of serum potassium with sacubitril/valsartan is lower than that of an ACE inhibitor or angiotensin receptor blocker. The combination is sometimes described as an "angiotensin receptor-neprilysin inhibitor" (ARNi). It was approved under the FDA's priority review process on July 7, 2015. It is also approved in Europe. In the USA, the wholesale cost for a year of sacubitril/valsartan is $4,560 per person as of 2015. Similar class generic drugs without sacubitril, such as valsartan alone, cost approximately $48 a year. One industry-funded analysis found a cost of $45,017 per QALY. The wholesale cost to the National Health Service in the UK is approximately £1,200 per person per year.