Scrabble?! CELEBRE

Definitions of CELEBRE in various dictionaries:

Celecoxib, sold under the brand name Celebrex among others, is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain in adults, painful menstruation, and juvenile rheumatoid arthritis in people two years or older.Side effects include a 37% increase in incidence of major vascular events, which include nonfatal myocardial infarction, nonfatal stroke, or death from a blood vessel-related cause. Additionally, an 81% increase in incidence of upper gastrointestinal complications occurs, which include perforations, obstructions, or gastrointestinal bleeding as in all nonsteroidal anti-inflammatory drugs (NSAIDs). In July 2015 the FDA strengthened the warning that non-aspirin NSAIDs can cause heart attacks or strokes.In the late 2000s, the American Heart Association warned that people at high risk for heart disease should only use celecoxib if there are no other possible treatments due to a higher risk of cardiac side-effects. However, a subsequent large-scale study has shown that it poses no greater risk for causing heart attacks and strokes than other frequently-used NSAIDs.Celecoxib is available by prescription in capsule form. It was initially marketed by Pfizer for arthritis. Prior to its availability in generic form, Celebrex was one of Pfizer's "best-selling drugs, amounting to more than $2.5 billion in sales [by 2012], and was prescribed to 2.4 million" people in 2011. By 2012, 33 million Americans had taken celecoxib. As of 2017, the average wholesale cost of the generic version is about $21 per month in the United States.