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tgivin
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There are 6 letters in TGIVIN ( G2I1N1T1V4 )
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| Tgivin might refer to |
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| Hormone replacement therapy (HRT), also known as menopausal hormone therapy (MHT) or postmenopausal hormone therapy (PHT, PMHT), is a form of hormone therapy which is used to treat symptoms associated with menopause in women. These symptoms can include hot flashes, vaginal atrophy and dryness, and bone loss, among others, and are caused by diminished levels of sex hormones in the menopausal period. The main hormonal medications used in HRT for menopausal symptoms are estrogens and progestogens. A progestogen is usually used in combination with an estrogen in women with intact uteruses because unopposed estrogen therapy is associated with endometrial hyperplasia and cancer and progestogens prevent these risks. Androgens like testosterone are sometimes used in HRT as well. HRT medications are available in various forms and for use by a variety of different routes of administration.The 2002 Women's Health Initiative (WHI) of the National Institutes of Health (NIH) found disparate results for all cause mortality with HRT, finding it to be lower when HRT was begun earlier, between age 50 to 59, but higher when begun after age 60. In older patients, there was an increased incidence of breast cancer, heart attacks and stroke, although a reduced incidence of colorectal cancer and bone fracture. Some of the WHI findings were again found in a larger national study done in the United Kingdom, known as the Million Women Study (MWS). As a result of these findings, the number of women taking HRT dropped precipitously. The WHI recommended that women with non-surgical menopause take the lowest feasible dose of HRT for the shortest possible time to minimize associated risks.The current indications for use from the United States Food and Drug Administration (FDA) include short-term treatment of menopausal symptoms, such as vasomotor hot flashes or vaginal atrophy, and prevention of osteoporosis. In 2012 and 2017, the United States Preventive Task Force (USPSTF) concluded that the harmful effects of combined estrogen and progestin therapy are likely to exceed the chronic disease prevention benefits in most women. A consensus expert opinion published by The Endocrine Society stated that when taken during perimenopause, or the initial years of menopause, HRT carries significantly fewer risks than previously published, and reduces all cause mortality in most patient scenarios. The American Association of Clinical Endocrinologists (AACE) also released a position statement in 2009 that approved of HRT in appropriate clinical scenarios. |