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protoheme
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The answer PROTOHEME has 0 possible clue(s) in existing crosswords.
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There are 9 letters in PROTOHEME ( E1H4M3O1P3R1T1 )
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Definitions of protoheme in various dictionaries:
noun - a complex red organic pigment containing iron and other atoms to which oxygen binds
PROTOHEME - Heme B or haem B (also known as protoheme IX) is the most abundant heme. Hemoglobin and myoglobin are examples of oxygen transport proteins that cont...
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a complex red organic pigment containing iron and other atoms to which oxygen binds |
Protoheme description |
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Heme B or haem B (also known as protoheme IX) is the most abundant heme. Hemoglobin and myoglobin are examples of oxygen transport proteins that contain heme B. The peroxidase family of enzymes also contain heme B. The COX-1 and COX-2 enzymes (cyclooxygenase) of recent fame, also contain heme B at one of two active sites. * Generally, heme B is attached to the surrounding protein matrix (known as the apoprotein) through a single coordination bond between the heme iron and an amino-acid side-chain. * Both hemoglobin and myoglobin have a coordination bond to an evolutionarily-conserved histidine, while nitric oxide synthase and cytochrome P450 have a coordination bond to an evolutionarily-conserved cysteine bound to the iron center of heme B. * Since the iron in heme B containing proteins is bound to the four nitrogens of the porphyrin (forming a plane) and a single electron donating atom of the protein, the iron is often in a pentacoordinate state. When oxygen or the toxic carbon monoxide i |