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flectors
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There are 8 letters in FLECTORS ( C3E1F4L1O1R1S1T1 )
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Plural form of flector. |
Flectors might refer to |
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Diclofenac (sold under a number of trade names) is a potent nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. It is supplied as or contained in medications under a variety of trade names. * The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cycloxygenase-2 (COX-2). Diclofenac has a low to moderate preference (10 fold) to block COX-1 and is said to have a lower incidence of gastrointestinal complaints than COX-1 inhibitores such as aspirin. Some evidence indicates it inhibits the lipoxygenase pathways which are related to inflammation,, and possibly phospholipase A2, as well as possibly phase inhibition (blockage) of voltage-dependent sodium channels, blockage of acid-sensing ion channels (ASICs) and positive allosteric modulation of KCNQ- and BK-potassium channels (related to hyperpolarization of the cell membrane). It also appears to exhibit bacteriostatic activity. Diclofenac lasts for around 6–8 hours in the body, possibly as it persists for over 11 hours in synovial fluids. * The name "diclofenac" derives from its chemical name: 2-(2,6-dichloranilino) phenylacetic acid. Diclofenac was first synthesized by Alfred Sallmann and Rudolf Pfister and introduced as Voltaren by Ciba-Geigy (now Novartis) in 1973, now by Glaxo SmithKline. In the United Kingdom, United States, India, and Brazil diclofenac may be supplied as either the sodium or potassium salt; in China, it is most often supplied as the sodium salt, while in some other countries it is only available as the potassium salt. It is available as a generic drug in a number of formulations, including diclofenac diethylamine, which is applied topically. Over-the-counter (OTC) use is approved in some countries for minor aches and pains and fever associated with common infections. As of 2015, the cost for a typical month of medication in the United States is US$50 to US$100. In European countries, the cost is no more than £8.40 (approx. US$10) for 24 weeks use.Use of diclofenac for animals is controversial due to toxicity when eaten by scavenging birds that eat dead animals; the drug has been banned for veterinary use in many countries. |