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emido
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There are 5 letters in EMIDO ( D2E1I1M3O1 )
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Emido might refer to |
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In molecular biology, the EMI domain, first named after its presence in proteins of the EMILIN family, is a small cysteine-rich protein domain of around 75 amino acids. The EMI domain is most often found at the N terminus of metazoan extracellular proteins that are forming or are compatible with multimer formation. It is found in association with other domains, such as C1q, laminin-type EGF-like, collagen-like, FN3, WAP, ZP or FAS1. It has been suggested that the EMI domain could be a protein-protein interaction module, as the EMI domain of EMILIN-1 was found to interact with the C1q domain of EMILIN-2.The EMI domain possesses six highly conserved cysteine residues, which likely form disulphide bonds. Other key features of the EMI domain are the C-C-x-G-[WYFH] pattern, a hydrophobic position just preceding the first cysteine (Cys1) of the domain and a cluster of hydrophobic residues between Cys3 and Cys4. The EMI domain could be made of two sub-domains, the fold of the second one sharing similarities with the C-terminal sub-module characteristic of EGF-like domains.Proteins known to contain an EMI domain include:* Vertebrate Emilins, extracellular matrix glycoproteins. * Vertebrate Multimerins, extracellular matrix glycoproteins. * Vertebrate Emu proteins, which could interact with several different extracellular matrix components and serve to connect and integrate the function of multiple partner molecules. * Vertebrate beta-IG-H3. * Vertebrate osteoblast-specific factor 2 (OSF-2). * Mammalian NEU1/NG3 proteins. * Drosophila midline fasciclin. * Caenorhabditis elegans ced-1, a transmembrane receptor that mediates cell corpse engulfment. |