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eculi
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There are 5 letters in ECULI ( C3E1I1L1U1 )
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Definitions of eculi in various dictionaries:
ECULI - Eculizumab, sold under the trade name Soliris, is a medication used to treat paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic ...
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Eculizumab, sold under the trade name Soliris, is a medication used to treat paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). It is a humanized monoclonal antibody functioning as a terminal complement inhibitor. In people with PNH, it reduces both the destruction of red blood cells and need for blood transfusion, but does not appear to affect the risk of death. Eculizumab was the first drug approved for each of its uses, and its approval was granted on the basis of small clinical trials.People who use it are greatly at risk for meningococcal infections and it is only prescribed to those who have enrolled in and follow a risk evaluation and mitigation strategy, which involves doctors counseling people to whom they are prescribing the drug, giving them educational materials, and ensuring that they are vaccinated, all of which must be documented. It is administered in a clinic by intravenous infusion. * It has been developed and is manufactured and marketed by Connecticut-based Alexion Pharmaceuticals, which has patent protection and administrative exclusivity on eculizumab until 2017. Alexion started selling Soliris in 2007 making $295 million in 2008 with its stock price rising 130% in 2010. In 2010, Soliris was the most expensive drug in the world. It costs £340,200 (approximately €430,000) per year for ongoing treatment in the UK, $500,000 a year in Canada, and US$409,500 a year in the United States (2010). In 2015, it was the 4th most expensive medication in the US on a per person treated basis. |