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dipic
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There are 5 letters in DIPIC ( C3D2I1P3 )
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Definitions of dipic in various dictionaries:
DIPIC - Dipicolinic acid (pyridine-2,6-dicarboxylic acid or PDC and DPA) is a chemical compound which composes 5% to 15% of the dry weight of bacterial spore...
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| (in the UK) Diploma in Education. |
| Dipic might refer to |
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| Dipicolinic acid (pyridine-2,6-dicarboxylic acid or PDC and DPA) is a chemical compound which composes 5% to 15% of the dry weight of bacterial spores. It is implicated as responsible for the heat resistance of the endospore.However, mutants resistant to heat but lacking dipicolinic acid have been isolated, suggesting other mechanisms contributing to heat resistance are at work.Dipicolinic acid forms a complex with calcium ions within the endospore core. This complex binds free water molecules, causing dehydration of the spore. As a result, the heat resistance of macromolecules within the core increases. The calcium-dipicolinic acid complex also functions to protect DNA from heat denaturation by inserting itself between the nucleobases, thereby increasing the stability of DNA.Two genera of bacterial pathogens are known to produce endospores: the aerobic Bacillus and anaerobic Clostridium.The high concentration of DPA in and specificity to bacterial endospores has long made it a prime target in analytical methods for the detection and measurement of bacterial endospores. A particularly important development in this area was the demonstration by Rosen et al. of an assay for DPA based on photoluminescence in the presence of terbium, although this phenomenon was first investigated for using DPA in an assay for terbium by Barela and Sherry. Extensive subsequent work by numerous scientists has elaborated on and further developed this approach. * It is also used to prepare dipicolinato ligated lanthanide and transition metal complexes for ion chromatography. |