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cullin
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There are 6 letters in CULLIN ( C3I1L1N1U1 )
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Definitions of cullin in various dictionaries:
CULLIN - Cullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They c...
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| Any of a family of proteins that have a role in protein degradation and ubiquitinylation |
| Cullin description |
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Cullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are highly diverse and play a role in myriad cellular processes, most notably protein degradation by ubiquitination.The human genome contains eight cullin genes* CUL1, part of SCF complex * CUL2, part of ECS complex (Elongin C - CUL2 - SOCS-box) * CUL3, part of CUL3-BTB complex * CUL4A * CUL4B * CUL5 * CUL7 * CUL9, also known as PARCThere is also a more distant member called ANAPC2 (or APC2), part of the Anaphase-promoting complex. * CUL1, 2, 3, 4A, 4B, 5 and 7 each form part of a multi-subunit ubiquitin complex. |