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catecho
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The answer CATECHO has 0 possible clue(s) in existing crosswords.
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There are 7 letters in CATECHO ( A1C3E1H4O1T1 )
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Definitions of catecho in various dictionaries:
CATECHO - Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disorder that predisposes those affected to potentially life-threatening...
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| Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disorder that predisposes those affected to potentially life-threatening abnormal heart rhythms or arrhythmias. The arrhythmias seen in CPVT typically occur during exercise or at times of emotional stress, and typically take the form of bidirectional ventricular tachycardia or ventricular fibrillation. Those affected may be asymptomatic, but may experience blackouts or even sudden cardiac death. * CPVT is caused by genetic mutations affecting proteins that regulate the concentrations of calcium within cardiac muscle cells. The most commonly identified gene is RYR2, encoding a protein encoding a channel known as the ryanodine receptor, which releases calcium from the cells internal calcium store, the sarcoplasmic reticulum, during every heartbeat. * CPVT is often diagnosed on an ECG recorded during an exercise tolerance test, but may also be diagnosed with a genetic test. The condition is treated with medication including beta-adrenoceptor blockers or flecainide, and with surgical procedures including sympathetic denervation and implantation of a defibrillator. * The condition is thought to affect as many as one in ten thousand people and is estimated to cause 15% of all unexplained sudden cardiac deaths in young people. CPVT was first recognised in 1960, and the underlying genetics were described in 2001. |