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zymogen
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The answer ZYMOGEN has 1 possible clue(s) in existing crosswords.
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Definitions of zymogen in various dictionaries:
noun - any of a group of compounds that are inactive precursors of enzymes and require some change (such as the hydrolysis of a fragment that masks an active enzyme) to become active
noun - a substance that develops into an enzyme when suitably activated
ZYMOGEN - A zymogen (), also called a proenzyme (), is an inactive precursor of an enzyme. A zymogen requires a biochemical change (such as a hydrolysis react...
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Inert precursor of many active proteins |
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Dec 29 2013 The Telegraph - General Knowledge |
Zymogen description |
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A zymogen (), also called a proenzyme (), is an inactive precursor of an enzyme. A zymogen requires a biochemical change (such as a hydrolysis reaction revealing the active site, or changing the configuration to reveal the active site) for it to become an active enzyme. The biochemical change usually occurs in Golgi bodies, where a specific part of the precursor enzyme is cleaved in order to activate it. The inactivating piece which is cleaved off can be a peptide unit, or can be independently folding domains comprising more than 100 residues. Although they limit the enzyme's ability, these n-terminal extensions of the enzyme or a prosegment often aid in the stabilizing and folding of the enzyme they inhibit. * The pancreas secretes zymogens partly to prevent the enzymes from digesting proteins in the cells in which they are synthesised. Enzymes like pepsin are created in the form of pepsinogen, an inactive zymogen. Pepsinogen is activated when chief cells release it into the gastric a |