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therapeu
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There are 8 letters in THERAPEU ( A1E1H4P3R1T1U1 )
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Definitions of therapeu in various dictionaries:
THERAPEU - The therapeutic index (TI; also referred to as therapeutic ratio) is a comparison of the amount of a therapeutic agent that causes the therapeutic ef...
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The therapeutic index (TI; also referred to as therapeutic ratio) is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity. The related terms therapeutic window or safety window refer to a range of doses which optimize between efficacy and toxicity, achieving the greatest therapeutic benefit without resulting in unacceptable side-effects or toxicity. * Classically, in an established clinical indication setting of an approved drug, TI refers to the ratio of the dose of drug that causes adverse effects at an incidence/severity not compatible with the targeted indication (e.g. toxic dose in 50% of subjects, TD50) to the dose that leads to the desired pharmacological effect (e.g. efficacious dose in 50% of subjects, ED50). In contrast, in a drug development setting TI is calculated based on plasma exposure levels.In the early days of pharmaceutical toxicology, TI was frequently determined in animals as lethal dose of a drug for 50% of the population (LD50) divided by the minimum effective dose for 50% of the population (ED50). Today, more sophisticated toxicity endpoints are used.* * * * * * Therapeutic * * Index * * * * = * * * * * * LD * * 50 * * * * * * * ED * * 50 * * * * * * * * * * * {\displaystyle {\ce {{Therapeutic\ Index}\ =\ {\frac {LD50}{ED50}}}}} * in animal studies, or for humans, * * * * * * Therapeutic * * Index * * * * = * * * * * * TD * * 50 * * * * * * * ED * * 50 * * * * * * * * * * * {\displaystyle {\ce {{Therapeutic\ Index}\ =\ {\frac {TD50}{ED50}}}}} * For many drugs, there are severe toxicities that occur at sublethal doses in humans, and these toxicities often limit the maximum dose of a drug. A higher therapeutic index is preferable to a lower one: a patient would have to take a much higher dose of such a drug to reach the toxic threshold than the dose taken to elicit the therapeutic effect. * Generally, a drug or other therapeutic agent with a narrow therapeutic range (i.e. having little difference between toxic and therapeutic doses) may have its dosage adjusted according to measurements o... |