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stringent
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The answer STRINGENT has 56 possible clue(s) in existing crosswords.
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The word STRINGENT is VALID in some board games. Check STRINGENT in word games in Scrabble, Words With Friends, see scores, anagrams etc.
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Definitions of stringent in various dictionaries:
adj - demanding strict attention to rules and procedures
Imposing rigorous standards of performance; severe: stringent safety measures.
Constricted; tight: operating under a stringent time limit.
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The stringent response, also called stringent control, is a stress response of bacteria and plant chloroplasts in reaction to amino-acid starvation, fatty acid limitation, iron limitation, heat shock and other stress conditions. The stringent response is signaled by the alarmone (p)ppGpp, and modulates transcription of up to 1/3 of all genes in the cell. This in turn causes the cell to divert resources away from growth and division and toward amino acid synthesis in order to promote survival until nutrient conditions improve. * In Escherichia coli, (p)ppGpp production is mediated by the ribosomal protein L11 (rplK resp. relC) and the ribosome-associated (p)ppGpp synthetase I, RelA; deacylated tRNA bound in the ribosomal A-site is the primary induction signal. RelA converts GTP and ATP into pppGpp by adding the pyrophosphate from ATP onto the 3' carbon of the ribose in GTP, releasing AMP. pppGpp is converted to ppGpp by the gpp gene product, releasing Pi. ppGpp is converted to GDP by the |