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nucleotidase
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Definitions of nucleotidase in various dictionaries:
An enzyme that catalyzes the hydrolysis of a nucleotide to a nucleoside and phosphoric acid.
NUCLEOTIDASE - A nucleotidase is a hydrolytic enzyme that catalyzes the hydrolysis of a nucleotide into a nucleoside and a phosphate. A nucleotide + H2O = a nucle...
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An enzyme that catalyzes the hydrolysis of a nucleotide to a nucleoside and phosphoric acid. |
Nucleotidase description |
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A nucleotidase is a hydrolytic enzyme that catalyzes the hydrolysis of a nucleotide into a nucleoside and a phosphate. * A nucleotide + H2O = a nucleoside + phosphateFor example, it converts adenosine monophosphate to adenosine, and guanosine monophosphate to guanosine. * Nucleotidases have an important function in digestion in that they break down consumed nucleic acids. * They can be divided into two categories, based upon the end that is hydrolyzed: * * EC 3.1.3.5: 5'-nucleotidase - NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3 * EC 3.1.3.6: 3'-nucleotidase - NT35'-Nucleotidases cleave off the phosphate from the 5' end of the sugar moiety. They can be classified into various kinds depending on their substrate preferences and subcellular localization. Membrane-bound 5'-nucleotidases display specificity toward adenosine monophosphates and are involved predominantly in the salvage of preformed nucleotides and in signal transduction cascades involving purinergic receptors. Soluble 5'-nucleotidases are all |