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neurofibrils
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Plural form of neurofibril. |
Neurofibrils might refer to |
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Neurofilaments (NF) are intermediate filaments found in the cytoplasm of neurons. They are protein polymers measuring approximately 10 nm in diameter and many micrometers in length. Together with microtubules and microfilaments, they form the neuronal cytoskeleton. They are believed to function primarily to provide structural support for axons and to regulate axon diameter, which influences nerve conduction velocity. The proteins that form neurofilaments are members of the intermediate filament protein family, which is divided into 6 classes based on their gene organization and protein structure. Class I and II are the keratins which are expressed in epithelia. Class III contains the proteins vimentin, desmin, peripherin and glial fibrillary acidic protein (GFAP). Note that the neuronal intermediate filament protein peripherin, which was named by Portier and colleagues in 1983, should not be confused with another protein of the same name (also known as peripherin-2 or peripherin-2 |