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necrotize
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Possible Dictionary Clues |
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To undergo necrosis or cause to necrose. |
(with reference to cells) die or cause to die owing to disease, injury, or failure of the blood supply. |
Necrotize might refer to |
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Necrosis (from the Greek "death, the stage of dying, the act of killing" from "dead") is a form of cell injury which results in the premature death of cells in living tissue by autolysis.Necrosis is caused by factors external to the cell or tissue, such as infection, toxins, or trauma which result in the unregulated digestion of cell components. * In contrast, apoptosis is a naturally occurring programmed and targeted cause of cellular death. * While apoptosis often provides beneficial effects to the organism, necrosis is almost always detrimental and can be fatal.Cellular death due to necrosis does not follow the apoptotic signal transduction pathway, but rather various receptors are activated, and result in the loss of cell membrane integrity and an uncontrolled release of products of cell death into the extracellular space.This initiates in the surrounding tissue an inflammatory response which attracts leukocytes and nearby phagocytes which eliminate the dead cells by phagocytosis. Ho |