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meromyosins
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In Human anatomy, Myosin, of which Meromyosin is a part of, along with actin constitute the basic functional unit of a muscle fiber, called Sarcomere. A better understanding of this subject can be reached once Muscle contraction is understood. * In biochemistry, meromyosin (mero meaning "part of") are subunits of the actin-associated motor protein, myosin, formed by trypsin digestion (proteolysis). Following digestion, two types of meromyosin are formed: heavy meromyosin (HMM) and light meromyosin (LMM). * Light meromyosin has a long, straight portion in the “tail” region. Heavy meromyosin is a protein chain terminating in a globular head portion/cross bridge. HMM consists of two subunits, Heavy Meromyosin Subunit 1 and 2 (HMMS-1 and HMMS-2). The majority of myosin activity is concentrated in HMMS-1. HMMS-1 has an Actin binding site and ATP binding site (myosin ATPase) that determines the rate of muscle contraction when muscle is stretched. * Light and Heavy meromyosin are subunits of Myosin filaments (thick myofilaments). |