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melphalans
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Definitions of melphalans in various dictionaries:
noun - antineoplastic drug (trade name Alkeran) used to treat multiple myeloma and some other malignancies
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| A nitrogen mustard given orally and intravenously in the treatment of multiple myeloma and other neoplasms 4-bis(2-chloroethyl)amino-l-phenylalanine, CHClNO. |
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Melphalan (trade name Alkeran, in former USSR also known as Sarcolysin) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. * An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring. * Otherwise known as L-phenylalanine mustard, or L-PAM, melphalan is a phenylalanine derivative of chlormethine. |