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marrowed
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The answer MARROWED has 0 possible clue(s) in existing crosswords.
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Definitions of marrowed in various dictionaries:
verb - to enter into marriage
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| Possible Dictionary Clues |
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| bmarrow definitionb. The soft, specialized connective tissue that fills the cavities of bones. One kind of bone bmarrowb is responsible for manufacturing red blood cells in the body. |
| A long white-fleshed gourd with green skin, which is eaten as a vegetable. |
| The plant of the gourd family which produces marrows. |
| A soft fatty substance in the cavities of bones, in which blood cells are produced. |
| The essential part of something. |
| A friend, companion, or workmate (often used as a form of address) |
| Something that forms a pair with something else a counterpart or twin. |
| Marrowed might refer to |
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| Marrow adipose tissue (MAT) , also known as bone marrow adipose tissue (BMAT), increases in states of low bone density -osteoporosis, anorexia nervosa/ caloric restriction, skeletal unweighting, anti-diabetes therapies). The marrow adipocytes originate from mesenchymal stem cell (MSC) progenitors that also give rise to osteoblasts, among other cell types. Thus, it is thought that MAT results from preferential MSC differentiation into the adipocyte, rather than osteoblast, lineage in the setting of osteoporosis. Since MAT is increased in the setting of obesity and is suppressed by endurance exercise, or vibration, it is likely that MAT physiology- in the setting of mechanical input/exercise- approximates that of white adipose tissue (WAT). The first study to demonstrate exercise regulation of MAT in rodents was published in 2014; now, exercise regulation of MAT has been confirmed in a human study as well adding clinical significance to this work. * MAT has qualities of both white and brown fat. Subcutaneous white fat contain excess energy, indicating a clear evolutionary advantage during times of scarcity. WAT is also the source of adipokines and inflammatory markers which have both positive (e.g., adiponectin) and negative effects on metabolic and cardiovascular endpoints. Visceral abdominal fat (VAT) is a distinct type of WAT that is "proportionally associated with negative metabolic and cardiovascular morbidity", regenerates cortisol, and recently has been tied to decreased bone formation Both types of WAT substantially differ from brown adipose tissue (BAT) as by a group of proteins that help BAT’s thermogenic role. MAT, by its "specific marrow location, and its adipocyte origin from at least LepR+ marrow MSC is separated from non-bone fat storage by larger expression of bone transcription factors", and likely indicates a different fat phenotype. Recently, MAT was noted to "produce a greater proportion of adiponectin - an adipokine associated with improved metabolism - than WAT", suggesting an endocrine function for this depot, akin, but different, from that of WAT. |