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ligases
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Definitions of ligases in various dictionaries:
adj - a complex protein [n -S] : ENZYMIC
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| Plural form of ligase. |
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In biochemistry, a Ligase is an enzyme that can catalyze the joining of two large molecules by forming a new chemical bond, usually with accompanying hydrolysis of a small pendant chemical group on one of the larger molecules or the enzyme catalyzing the linking together of two compounds, e.g., enzymes that catalyze joining of C-O, C-S, C-N, etc. In general, a ligase catalyzes the following reaction:* Ab + C AC + bor sometimes * * Ab + cD AD + b + c + d + e + fwhere the lowercase letters can signify the small, dependent groups. Ligase can join two complementary fragments of nucleic acid and repair single stranded breaks that arise in double stranded DNA during replication. |