Crossword Solver > found answer > CYCLOSPORINE

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cyclosporine

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Definitions of cyclosporine in various dictionaries:

An immunosuppressive drug obtained from certain soil fungi, used mainly to prevent the rejection of transplanted organs.

CYCLOSPORINE - Ciclosporin, also spelled cyclosporine and cyclosporin, is an immunosuppressant medication and natural product. It is taken by mouth or by injection ...

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Possible Jeopardy Clues
Synthesized from soil fungi, this drug reduces rejection following organ transplants
A chemical found in a Norwegian fungus became this immuno-suppressant drug that made organ transplants safer

Possible Dictionary Clues
An immunosuppressive drug obtained from certain soil fungi, used mainly to prevent the rejection of transplanted organs.
an immunosuppressant drug ( a drug used to deliberately stop the body's immune system from working):
A drug with immunosuppressive properties used to prevent the rejection of grafts and transplants. A cyclic peptide, it is obtained from a fungus.

Cyclosporine might refer to
Ciclosporin, also spelled cyclosporine and cyclosporin, is an immunosuppressant medication and natural product. It is taken by mouth or by injection into a vein for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, and in organ transplants to prevent rejection. It is also used as eye drops for keratoconjunctivitis sicca (dry eyes).Common side effects include high blood pressure, headache, kidney problems, increased hair growth, and vomiting. Other severe side effects include an increased risk of infection, liver problems, and an increased risk of lymphoma. Blood levels of the medication should be checked to decrease the risk of side effects. Use during pregnancy may result in preterm birth; however, ciclosporin does not appear to cause birth defects.Ciclosporin is believed to work by decreasing the function of lymphocytes. It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin, which in turn decreases the production of inflammatory cytokines by T‐lymphocytes.Ciclosporin was isolated in 1971 from the fungus Tolypocladium inflatum and came into medical use in 1983. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$106.50 a month. In the United Kingdom, it costs the NHS about GB£121.25 per month. The wholesale price in the United States is about US$172.95 per month.*

Cyclosporine might refer to

Ciclosporin, also spelled cyclosporine and cyclosporin, is an immunosuppressant medication and natural product. It is taken by mouth or by injection into a vein for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, and in organ transplants to prevent rejection. It is also used as eye drops for keratoconjunctivitis sicca (dry eyes).Common side effects include high blood pressure, headache, kidney problems, increased hair growth, and vomiting. Other severe side effects include an increased risk of infection, liver problems, and an increased risk of lymphoma. Blood levels of the medication should be checked to decrease the risk of side effects. Use during pregnancy may result in preterm birth; however, ciclosporin does not appear to cause birth defects.Ciclosporin is believed to work by decreasing the function of lymphocytes. It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin, which in turn decreases the production of inflammatory cytokines by T‐lymphocytes.Ciclosporin was isolated in 1971 from the fungus Tolypocladium inflatum and came into medical use in 1983. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$106.50 a month. In the United Kingdom, it costs the NHS about GB£121.25 per month. The wholesale price in the United States is about US$172.95 per month.*

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