Welcome to Anagrammer Crossword Genius! Keep reading below to see if canakinumab is an answer to any crossword puzzle or word game (Scrabble, Words With Friends etc). Scroll down to see all the info we have compiled on canakinumab.
canakinumab
Searching in Crosswords ...
The answer CANAKINUMAB has 0 possible clue(s) in existing crosswords.
Searching in Word Games ...
The word CANAKINUMAB is NOT valid in any word game. (Sorry, you cannot play CANAKINUMAB in Scrabble, Words With Friends etc)
There are 11 letters in CANAKINUMAB ( A1B3C3I1K5M3N1U1 )
To search all scrabble anagrams of CANAKINUMAB, to go: CANAKINUMAB
Rearrange the letters in CANAKINUMAB and see some winning combinations
6 letters out of CANAKINUMAB
5 letters out of CANAKINUMAB
4 letters out of CANAKINUMAB
3 letters out of CANAKINUMAB
Searching in Dictionaries ...
Definitions of canakinumab in various dictionaries:
CANAKINUMAB - Canakinumab (INN, trade name Ilaris, previously ACZ885) is a human monoclonal antibody targeted at interleukin-1 beta. It has no cross-reactivity wit...
Word Research / Anagrams and more ...
Keep reading for additional results and analysis below.
| Canakinumab might refer to |
|---|
| Canakinumab (INN, trade name Ilaris, previously ACZ885) is a human monoclonal antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha.Canakinumab was approved for the treatment of cryopyrin-associated periodic syndromes (CAPS) by the U.S. Food and Drug Administration (FDA) in June 2009 and by the European Medicines Agency in October 2009. CAPS is a spectrum of autoinflammatory syndromes including familial cold autoinflammatory syndrome, Muckle–Wells syndrome, and neonatal-onset multisystem inflammatory disease. * In September 2016, FDA approved the use of canakinumab on 3 additional rare and serious auto-inflammatory diseases: Tumor necrosis factor receptor associated periodic syndrome (TRAPS), Hyperimmunoglobulin D syndrome (HIDS)/Mevalonate kinase deficiency (MKD) and Familial Mediterranean fever (FMF). * Canakinumab was being developed by Novartis for the treatment of rheumatoid arthritis, but this trial was completed in October 2009. Canakinumab is also in phase I clinical trials as a possible treatment for chronic obstructive pulmonary disease, gout, and coronary artery disease (the CANTOS trial;). It is also in trials for schizophrenia. In gout, it may result in better outcomes than a low dose of a steroid, but costs five thousand times more.. One 150 mg subcutaneous injection, usually needed every two weeks, costs over $16,700; discounts are sometimes available.On Aug 27, 2017, the results of the CANTOS trial were announced at the European Society of Cardiology and published Lancet and the New England Journal of Medicine. Those treated in CANTOS had a 15% reduction in deaths from heart attacks, stroke and cardiovascular disease combined. However, there were serious side-effects, and no statistically significant overall survival benefit. Nonetheless, David Goff, director of the division of cardiovascular sciences at the National Heart, Lung and Blood Institute feels the "public health impact potential is really substantial,” and estimates that in the United States 3 million people might benefit from canakinumab. Further analysis on data from the CANTOS trial also showed a significant reduction in lung cancer incidence and mortality in the canakinumab treated group compared to placebo. |