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alestrae
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There are 8 letters in ALESTRAE ( A1E1L1R1S1T1 )
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Alestrae might refer to |
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Alestramustine (INN), also known as estradiol 3-(bis(2-chloroethyl)carbamate) 17β-(L-alaninate), is a nitrogen mustard alkylating antineoplastic drug that was never marketed. It is the L-alanine ester of estramustine, which is a combination of the nitrogen mustard normustine coupled via a carbamate to the estrogen estradiol. Alestramustine acts as a prodrug to estramustine, and also forms estradiol as a byproduct. The drug, via its active metabolites, binds to microtubule-associated proteins and β-tubulin and interferes with microtubule function, thereby inhibiting cell division. Due to its estrogen moiety, alestramustine is selectively concentrated in estrogen receptor-positive cells such as prostate and breast. |