Scrabble?! OXYCODONES

Definitions of OXYCODONES in various dictionaries:

Oxycodone, sold under brand names such as Percocet and OxyContin among many others, is an opioid medication which is used for the relief of moderate to severe pain. It is usually taken by mouth, and is available as a single-ingredient medication in immediate release and controlled release formulations. In the United Kingdom, it is available in 10 mg/mL and 50 mg/mL formulation for intramuscular or intravenous administration. Combination products are also available as immediate-release formulations, with non-narcotic analgesic ingredients such as paracetamol (acetaminophen) and nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin and ibuprofen. Side effects of oxycodone include constipation, nausea, vomiting, somnolence, dizziness, itching, dry mouth, and sweating. The medication can produce euphoria and can result in addiction, dependence, and withdrawal symptoms upon discontinuation. With overdose, oxycodone can cause respiratory depression, slowed heart rate, low blood pressure, circulatory collapse, respiratory arrest, and death. Oxycodone is an opioid, and acts as a selective agonist of the μ-opioid receptor, the main biological target of the endogenous neuropeptide β-endorphin. It is a moderately potent opioid pain medication (orally roughly 1.5 times more potent than morphine).Oxycodone is a semisynthetic opioid derived from thebaine, an opioid alkaloid found in the Persian poppy and one of the many alkaloids found in the opium poppy. Oxycodone was developed in 1917 in Germany as one of several semisynthetic opioids in an attempt to improve on the existing opioids. As it has euphoric effects similar to other opioids, oxycodone is one of the drugs abused in the current opioid epidemic in the United States. An abuse-deterrent combination with naloxone is available in managed-release tablets. If injected, the naloxone blocks the effect of the medication and precipitates opioid withdrawal symptoms. However, there have been concerns raised about the effectiveness of the abuse prevention measures.